Saturday, September 22
From 17:00 Registration
18:15 – 20:00 Dinner
20:00 – 20:15 Opening of the symposium
20:15 – 21:00 Helmut Holzer Memorial Lecture
Michael Groll: Drug discovery in the ubiquitin proteasome pathway
[chair Vito Turk]
21:00 – 23:00 Get-Together
Sunday, September 23
Cysteine Cathepsins: friend and foes
[Chair: Christoph Peters]
9:00 – 9:25 Klaudia Brix: Cysteine cathepsin variants in the intestine, skin, and thyroid – trafficking pathways, interaction partners and possible functions in physiology and disease
9:25 – 9:50 Gilles Lalmanach: Human cysteine cathepsins in pulmonary fibrosis
9:50 – 10:15 Lukas Mach: Human cathepsin O: glycosylation, processing and cellular activity
10:15 – 10:30 Christine Watson: Regulation and function of Cathepsin L in mammary gland involution
10:30 – 11:00 COFFEE BREAK
The World of Inhibitors
[Chair: Walter Stoecker, Francesc Aviles]
11:00 – 11:25 Francesc X. Aviles: Advances on M14 metallocarboxypeptidases and inhibitors: from the deep profiling of specificities to new functionalities
11:25 – 11:50 Walter Stoecker: Control of Astacin Metalloproteases by Natural Inhibitors
11:50 – 12:05 Eva Žerovnik: On possible function and toxicity of multiple oligomeric / conformational states of human stefin B.
12:05 – 12:20 Marko Novinec: Human testican-3, a novel thyropin with unique characteristics
12:20 – 12:35 Jerica Sabotič: Structure and function of protease inhibitors and lectins from mushrooms
12:35 – 12:50 Tina Zavašnik: Inhibition of human cathepsins S and L by the salivary cystatin-type inhibitor OmC2 from the tick Ornithodoros moubata
12:50 – 15:00 LUNCH BREAK
Is there a structure?
[Chair: Dušan Turk]
15:00 – 15:25 James Huntington: How and why the Z variant of α1-antitrypsin polymerises, and what can be done about it
15:25 – 15:40 Tom Murray-Rust: Crystal structure of the prothrombinase complex from Pseudonaja textilis reveals the likely structure of the human prothrombinase complex
15:40 – 16:05 Robert Pike: The zymogen form of the catalytic region of the complement protease, C1s, is stabilized into a form unable to interact with substrates and cofactors
16:05 – 16:30 Hans Brandstetter: The activation peptides of fIX and fX undergo a disorder-order transition upon ligand binding
16:30 – 17:00 COFFEE BREAK
Protease cocktail
[Chair: Rob Pike]
17:00 – 17:15 Marcin Drag: Hybride combinatorial substrate libraries for profiling endoproteases substrate specificity
17:15 – 17:30 Dmitriy Minond: Discovery of Novel Inhibitors of ADAM17 Using Glycosylated and Non-Glycosylated Substrates And Combinatorial Library Approach
17:30 – 17:45 Anthony O'Donoghue: Global Identification of Proteinase Specificity by Multiplex Substrate Profiling
17:45 – 18:00 Brenda Oppert: Expression patterns of digestive peptidases in larvae of the tenebrionids 'Tenebrio molitor' and 'Tribolium castaneum'
18:00 – 18:15 Thomas Zögg: The structural basis of autoproteolysis and immune modulation by the pestiviral protein Npro.
18:35 – 20:00 DINNER
20:00 – 21:30 POSTER SESSION I (and social activities)
Monday, September 24
Death and Survival
[Chair: Peter Vandenabeele]
9:00 – 9:25 Guy Salvesen: Caspases, Paracaspase, and the Space Between Death and Survival
9:25 – 9:50 Petra Van Damme: The substrate repertoire of the aggregate-clearing yeast metacaspase Yca1
9:50 – 10:15 Boris Zhivotovsky: Contribution of caspase-2 for cleavage of substrates during cell death
10:15 – 10:40 Gunnar Pejler: A serglycin proteoglycan/tryptase axis promotes apoptotic versus necrotic cell death in mast cells
10:40 – 11:00 COFFEE BREAK
[Chair: Boris Zhivotovsky]
11:00 – 11:25 Peter Vandenabeele: Role of proteases and kinases in TNF-induced necroptosis
11:25 – 11:50 Hans-Uwe Simon: p73 regulates hepatocellular lipid metabolism
11:50 – 12:05 Veronika Stoka: Structural and functional network of ataxin 3: human vs mouse models
12:05 – 12:30 Sponsor presentations
12:30 – 15:00 LUNCH BREAK
Inflammation, tumours, …
[Chair: Gilles Lalmanach]
15:00 – 15:25 Jan Potempa: Proteolytic activity of Porphyromonas gingivalis as the sole virulence factor in the development of aspiration pneumonia
15:25 – 15:50 Kenji Yamamoto: Cathepsin E: Related signaling systems, functions and implication in diseases
15:50 – 16:05 Walter Halangk: Zymogen Activation, Cell Injury and Inflammation in Acute Pancreatitis
16:05 – 16:20 Nataša Kopitar Jerala: Cysteine proteinase inhibitors modulate innate immune response
16:20 – 16:50 COFFEE BREAK
[Chair: Klaudia Brix]
16:50 – 17:15 Thomas Reinheckel: Distinct roles for endolysosomal cysteine proteases in the macrophage response to Staphylococcus aureus
17:15 – 17:30 Christoph Peters: Impact of Mircoenvironmental Proteolytic Capacity on Cancer Cell Invasion and Metastasis
17:30 – 17:45 Marko Fonović: Cysteine cathepsins effect tumor cell migration and invasion through the shedding of protein ectodomains
17:45 – 18:00 Chris Scott: Cathepsin S produced from both tumour and infiltrating stromal cells is essential to promote tumour neovascularisation and growth
18:00 – 20:00 DINNER
20:00 – 21:30 POSTER SESSION II (and social activities)
Tuesday, September 25
Alzheimer, clinics, calpains, …
[Chair: Guy Salvesen]
9:00 – 9:25 Hans-Ulrich Demuth: Glutaminyl cyclase inhibitors attenuating neurodegeneration and neurinflammation in models of Alzheimer‘s disease are now at clinical stage
9:25 – 9:50 Manuel Than: Specific metal binding dictates the conformation of the APP-E2 domain
9:50 – 10:15 Hiroyuki Sorimachi: Towards understanding the enigmatic substrate specificity of calpains
10:15 – 10:40 Yasuhiko Ozaki: Calpain in human reproduction: role of calpain in human placenta of patients with intrauterine growth restriction
10:40 – 11:00 COFFEE BREAK
11:00 – 11:45 Closing keynote lecture
Joseph A. Trapani: Mouse granzyme A mediates a novel, non-apoptotic form of cell death
[Chair: Boris Turk]
11:45 – 12:00 Closing of the Symposium
12:00 – 20:00 Lunch and Free afternoon
20:00 – 24:00 Gala dinner
Wednesday, September 26
Hotel check-out & Departure